The European Chemicals Agency’s Risk Assessment Committee reviewed the 2025 Ramazzini Institute study and public comments, and concluded the new data do not change its 2022 hazard assessment that glyphosate does not warrant a carcinogenic classification.
ECHA’s RAC reviewed the 2025 Global Glyphosate Study (Ramazzini Institute) and sustained its 2022 decision that glyphosate does not require a carcinogenic classification.
The Ramazzini study exposed thousands of rats in utero and for 104 weeks and reported dose-related increases in multiple malignant tumors, but RAC’s independent assessment found the study insufficient to change the hazard conclusion.
Agency (ECHA) Risk Assessment Committee (RAC) met on September 8, 2026, and concluded that glyphosate does not warrant classification as a carcinogen. That conclusion reaffirms RAC's hazard assessment issued in 2022.
Over two years, thousands of rats were exposed to glyphosate via their mothers' drinking water in utero and then directly through drinking water for the remainder of a 104-week lifespan. The study reported multiple tumor increases, including leukemia-like cancers, at dose levels at or below EU reference points such as the Acceptable Daily Intake (ADI) and No Observed Adverse Effect Level (NOAEL).
RAC carried out an independent scientific assessment of the Ramazzini data and considered public comments submitted during a March 2026 consultation. Following that review, RAC determined the new study does not change the conclusions of its 2022 hazard assessment: glyphosate does not require classification for carcinogenicity.
Cancer classified glyphosate as a "probable carcinogen" in 2015. Academic institutions such as Wageningen University and Research have criticized EFSA's 2023 risk assessment, arguing it did not apply the precautionary principle and may have overlooked certain exposure routes and risks.
RAC said an official explanation of its opinion will be published on ECHA's website within a few months. That document will outline the committee's scientific reasoning and how it weighed the Ramazzini study against existing evidence and regulatory assessments.
Regulators: ECHA's position maintains the existing EU hazard classification framework for glyphosate and supports the prior renewal decision.
Industry and users: Current EU authorization and conditions of use remain in effect pending any new regulatory action.
Researchers and public-health advocates: The Ramazzini study and the RAC response will likely be referenced in ongoing scientific and policy debates about study design, exposure assessment, and long-term animal studies.
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