Ufd1 Unfolds Ubiquitin Without ATP to Kick-Start Cdc48/p97 Waste Disposal
For years, researchers have known that this machine, a hexameric AAA+ ATPase, depends on its cofactors […]
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For years, researchers have known that this machine, a hexameric AAA+ ATPase, depends on its cofactors […]
Inside every cell, a molecular machine called Cdc48—known as p97 or VCP in humans—works around the clock to drag damaged, mislocated, or otherwise doomed proteins out of membranes and protein complexes so...
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For years, researchers have known that this machine, a hexameric AAA+ ATPase, depends on its cofactors […] Inside every cell, a molecular machine called Cdc48—known as p97 or VCP in humans—works around the clock to drag damaged, mislocated, or otherwise doomed proteins out of membranes and protein complexes so they can be shredded by the proteasome.
How it works
- Inside every cell, a molecular machine called Cdc48—known as p97 or VCP in humans—works around the clock to drag damaged, mislocated, or otherwise doomed proteins out of membranes and protein complexes so...
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