Plos iconPlosSep 11, 2026 ~1 min source read

Leveraging perturbations to infer the population dynamics of human rhinovirus and interaction of influenza A virus

Yet, how pathogen community structure shapes the dynamics of infectious diseases remains poorly understood. At the population level, investigating polymicrobial dynamics, with potential underlying competitive or cooperative interactions, is challenging, because of confounding factors such as differing seasonality.

Leveraging perturbations to infer the population dynamics of human rhinovirus and interaction of influenza A virus

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Yet, how pathogen community structure shapes the dynamics of infectious diseases remains poorly understood.

At the population level, investigating polymicrobial dynamics, with potential underlying competitive or cooperative interactions, is challenging, because of confounding factors such as differing seasonality.

This is particularly true for endemic pathogens which typically exhibit stable periodic dynamics.

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The useful part

Yet, how pathogen community structure shapes the dynamics of infectious diseases remains poorly understood. At the population level, investigating polymicrobial dynamics, with potential underlying competitive or cooperative interactions, is challenging, because of confounding factors such as differing seasonality. This is particularly true for endemic pathogens which typically exhibit stable periodic dynamics.

How it works

  • by Wakinyan Benhamou, Emily Howerton, Sang Woo Park, Cécile Viboud, C.
  • Here, we focus on the population dynamics of human rhinovirus (common cold) and on the potential viral interference of influenza A virus (flu A), which is hypothesized to account for their asynchronous...
  • We estimate key parameters of rhinovirus but find no conclusive support for an influence of influenza A virus at the population level.

What to take from it

Their disruption due to the implementation of non-pharmaceutical interventions during the COVID-19 pandemic thus represents a unique large-scale natural experiment that can be leveraged to provide valuable insights into the complex interplay between respiratory pathogens.

Details worth keeping

Grenfell Many respiratory pathogens co-circulate within human populations.

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