Phys iconPhysSep 18, 2026

Discovery of CRISPR's long lost ancestor may expand gene-editing toolkit

CRISPR may be a powerful technology for gene editing, but the system existed in bacteria long before scientists began using it. For billions of years, CRISPR has acted as a natural immune system in bacteria and other microbes, helping defend them against invading viruses.

Discovery of CRISPR's long lost ancestor may expand gene-editing toolkit

Share this story

Send the public story page.

Useful takeaways from this story.

CRISPR may be a powerful technology for gene editing, but the system existed in bacteria long before scientists began using it.

For billions of years, CRISPR has acted as a natural immune system in bacteria and other microbes, helping defend them against invading viruses.

Now, two new studies, published in Science, describe a similar RNA-guided system that originated in the viruses themselves and appears to be a precursor to CRISPR.

Building the complete brief

The page is ready to read now. The fuller skim-friendly version will appear here automatically.

The useful part

CRISPR may be a powerful technology for gene editing, but the system existed in bacteria long before scientists began using it. For billions of years, CRISPR has acted as a natural immune system in bacteria and other microbes, helping defend them against invading viruses. Now, two new studies, published in Science, describe a similar RNA-guided system that originated in the viruses themselves and appears to be a precursor to CRISPR.

Keep reading in the app

Open the app view to save this story, compare related coverage, and continue from the same source.

Open in app