The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the inflammatory response to damage and dysfunction. Nothing in the cell has only one purpose, however, and cGAS is also involved in the regulation of the DNA damage response in the cell nucleus.
The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the inflammatory response to damage and dysfunction.
Nothing in the cell has only one purpose, however, and cGAS is also involved in the regulation of the DNA damage response in the cell nucleus.
It is known to inhibit homologous recombination of double strand breaks, for example.
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The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the inflammatory response to damage and dysfunction. Nothing in the cell has only one purpose, however, and cGAS is also involved in the regulation of the DNA damage response in the cell nucleus. It is known to inhibit homologous recombination of double strand breaks, for example.
The cGAS-STING interaction produces some fraction of the maladaptive chronic inflammation characteristic of aging, as, among other reasons, mitochondrial dysfunction tends to spill mitochondrial DNA fragments into the cell cytoplasm.
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