Psychedelicalpha iconPsychedelicalphaSep 25, 2026 ~3 min source read

Pα+ Psychedelic Bulletin #232: Q2’26 Lobbying Surge; DEA Revisits Schedule 5 Tryptamines; Oregon Shelves Psilocybin Fee Hike

Quarterly federal lobbying figures show rising spending by psychedelic companies; the DEA renewed a move to reschedule certain tryptamines; Oregon abandoned a proposed psilocybin fee increase; research and financing updates round out the bulletin.

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Federal lobbying by psychedelic companies rose in Q2 2026, approaching $350,000 in aggregate and led largely by Compass Pathways and Definium Therapeutics.

The DEA has revived an effort to place multiple tryptamines into Schedule 5 — a regulatory action that could affect research and access pathways.

Academic teams called for stronger blinding methods in psychedelic trials while BetterLife announced a $100M raise for a non-hallucinogenic headache candidate.

# Quick summary

Federal lobbying: activity climbs in Q2 2026

Psychedelic companies' spending on federal lobbying firms increased in Q2 2026, reaching just shy of $350,000 in total. That amount remains small compared with traditional healthcare and pharma lobbying, but it marks a distinct uptick for the psychedelic sector. The spending was driven principally by Compass Pathways and Definium Therapeutics.

  • Rising lobbying spend signals stronger engagement with federal policymakers as companies seek regulatory clarity and market access.
  • Even modest lobbying totals can shape rulemaking and appropriation conversations, especially in a niche policy area.

DEA: renewed move to schedule five tryptamines

Schedule 5. The bulletin reports the agency is again pursuing that regulatory path.

  • Scheduling changes can affect research approvals, clinical trial supply logistics, and commercial plans.

Oregon backpedals on psilocybin fee hike

Oregon shelved a proposed increase to fees tied to its psilocybin program after advocates and stakeholders criticized the hike. The bulletin frames this as a victory for advocates who opposed the higher fees.

  • Fee levels influence program economics for providers and participants.
  • State-level policy shifts remain a primary access route while federal frameworks evolve.

Research and clinical trial methods

Researchers at Stanford and UCSF called for "more aggressive" blinding strategies in psychedelic trials. The bulletin highlights this methodological critique as part of an ongoing debate over trial design and placebo control in psychedelic research.

  • Blinding quality affects internal validity and the interpretability of trial outcomes.

Financing and product development

BetterLife announced a $100 million financing to advance a non-hallucinogenic candidate targeting headache disorders. The bulletin lists this as a notable financing development in the space.

  • Significant capital raises for non-hallucinogenic approaches demonstrate investor interest in alternative mechanisms and indications beyond psychiatric uses.
  • Funding levels can accelerate preclinical and clinical progress.

Other headlines and context

The bulletin bundles additional items under "Other Headlines" but highlights the items above as primary developments for the quarter. The reporting continues a regular cadence of policy and industry tracking, combining public filings, regulatory action updates, research commentary, and financing news.

# Bottom line

More context around this story.

Psychedelicalpha iconPsychedelicalphaSep 16, 2026

Pα+ Psychedelic Bulletin #231: Compass Shares 52 Week Follow-Up, Training Grant Recipients; Xylo Enters the Clinic; RFK Jr. Hosts Hubbard

Compass Shares 52-Week Follow-Up and Five Training Grant Recipients Earlier this month, Compass Pathways shared topline data from Part C of its smaller, placebo-controlled Phase 3 trial, COMP005. As a reminder, COMP005 enrolled 258 patients with treatment-resistant depression (TRD) to receive either a 25 mg dose of the

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