Fightaging iconFightagingSep 25, 2026 ~1 min source read

Known Cancer-Associated Genetic Sequences are More Conserved in Long-Lived Species

Suppression of cancer is a necessary component of species longevity, and finding out how exactly cancer incidence is in some cases dramatically reduced is one of the primary goals for the field of comparative biology. Here, researchers survey known cancer-associated sequences across the genomes of long-lived and short-lived species, and see that sequences are more conserved in long-lived species.

Known Cancer-Associated Genetic Sequences are More Conserved in Long-Lived Species

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Suppression of cancer is a necessary component of species longevity, and finding out how exactly cancer incidence is in some cases dramatically reduced is one of the primary goals for the field of...

Here, researchers survey known cancer-associated sequences across the genomes of long-lived and short-lived species, and see that sequences are more conserved in long-lived species.

Patterns of epigenetic modifications to the genome at these locations also exhibit differences in long-lived species.

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Suppression of cancer is a necessary component of species longevity, and finding out how exactly cancer incidence is in some cases dramatically reduced is one of the primary goals for the field of comparative biology. Here, researchers survey known cancer-associated sequences across the genomes of long-lived and short-lived species, and see that sequences are more conserved in long-lived species. Patterns of epigenetic modifications to the genome at these locations also exhibit differences in long-lived species.

How it works

  • Recently, accumulated evidence has shown that longer-lived species, such as naked mole rats, elephants, and some bat species display […]
  • Thus one component of reduced cancer risk in these species involves specific sequence differences in oncogenes and related genes, and different expression of oncogenes in circumstances relevant to induction...

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