Plos iconPlosSep 28, 2026 ~1 min source read

A developmental single-cell atlas of the <i>Drosophila</i> visual system glia reveals cell type diversification and subcellular mRNA compartmentalization

We have experimentally validated these developmental trajectories and identified the genetic markers expressed through the differentiation between EG and ALG classes. We have identified that processes are enriched for distinct mRNAs that were validated in vivo.

A developmental single-cell atlas of the <i>Drosophila</i> visual system glia reveals cell type diversification and subcellular mRNA compartmentalization

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We have experimentally validated these developmental trajectories and identified the genetic markers expressed through the differentiation between EG and ALG classes.

We have identified that processes are enriched for distinct mRNAs that were validated in vivo.

This work provides the most detailed transcriptomic analysis of optic lobe glia during development and helps explain the expansion of glial diversity observed in the adult visual system.

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We have experimentally validated these developmental trajectories and identified the genetic markers expressed through the differentiation between EG and ALG classes. We have identified that processes are enriched for distinct mRNAs that were validated in vivo. This work provides the most detailed transcriptomic analysis of optic lobe glia during development and helps explain the expansion of glial diversity observed in the adult visual system.

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  • We also present an innovative computational approach to identify mRNA species that are differentially localized to cell bodies or cellular processes.

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