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by Siyao Wang, Laura Childers, Fernando Martinez III, Michel Bagnat, Jieun Park Lysosome-rich enterocytes (LREs) are a specialized population of intestinal cells that mediate the uptake and absorption of dietary proteins in fish and neonatal mammals. Loss of LRE function causes inhibited growth and poor survival due to
by Jake Colautti, Alexander C. Anderson, Wyatt P. K. Clark, Lindsey S. Marmont Bacterial cell division requires precise regulation of septal peptidoglycan (PG) synthesis by the essential SEDS-bPBP synthase FtsWI. Activation of FtsWI is thought to occur through an allosteric cascade initiated by the late-arriving diviso
by Sarah Frieda Becker, Marie-Charlotte Morin, Julien Lambert, Shashi Kumar Suman, Francesco Nicola Carelli, Alex Appert, Stéphane Roth, Sarah Hoff-Yoessle, Jessica D. Medina-Sanchez, Manuela Portoso, Julie Ahringer, Sophie Jarriault The mechanisms that restrict or enable latent cellular plasticity have attracted growi
by Penghui Song, Lijuan Ma, Dong Yan N 6 -methyladenosine (m 6 A), one of the most abundant chemical modifications on RNA, is installed by METTL3 and several other methyltransferases, including METTL16. Although METTL16 has been characterized in several model organisms, its function in Drosophila remains unknown. Here,
by Joshua Richland, Tuomo Kiiskinen, William Wang, Wenhui Sophia Lu, Balasubramanian Narasimhan, Trevor Hastie, Manuel Rivas, Robert Tibshirani We present a scalable framework for computing polygenic risk scores (PRS) in high-dimensional genomic settings using the recently introduced Univariate-Guided Sparse Regression
by Xinyan Gan, Qiwen Li, Qiuchan Xiong, Denghao Huang, Zizheng Liu, Qi Yin, Shuang Jiang, Takuma Matsubara, Shoichiro Kokabu, Wei Yan, Quan Yuan Rapid hair follicle cycling requires precise fate commitment and differentiation of hair follicle stem cells. While the essential role of transcription factors in establishing
by Nashaly Soto-Echevarria, Annabel S. Lemma, Mark P. Brynildsen Stationary-phase cultures contain high abundances of persisters, which are bacterial cells that are hyper-tolerant to antibiotics due to phenotypic reasons. Fluoroquinolones (FQs) are one of the most effective antibiotic classes for the treatment of non-g
by Shauna A. Rasmussen, Catherine M. Lemons, Madelyn M. Seemiller, Sabrina R. Dallas, Milan Cambon Ledesma, Yuhan Wu, Lauren E. Anshen, Ashlyn Farnham, Olivia S. Garrett, Judith L. Fridovich-Keil Classic galactosemia (CG) is a potentially lethal disease that results from profound deficiency of galactose-1-P uridylyltra
by Ruiqi Yuan, Jianzhi Zhang In bacteria with circular chromosomes, genes near the replication origin ( oriC ) are replicated earlier and consequently attain higher copy numbers than genes near the terminus ( ter ), particularly during rapid growth. Hence, mutations altering a gene’s chromosomal position can affect its
by Eirik Haugland Kvalvik, Yunpeng Wang, Kristine Beate Walhovd, Torkild Hovde Lyngstad, Ole Røgeberg Although educational attainment is heritable, years-of-education (EduYears) measures are not designed to show how genetic associations vary across discrete educational milestones. In the Norwegian Mother, Father and Ch
by Maria Paula Zappia, Anton Westacott, Hannah Cooke, Rhianna Geary, Libby Travers, Lucia de Castro, Oliver Carty, Maxim V. Frolov In Drosophila , Arginine kinase 1 (Argk1) is involved in maintaining ATP homeostasis during bursts of activity in tissues with high and variable rates of energy turnover such as muscle. How
by Elika Garg, Jaffa Romain, Lei Sun, Andrew D. Paterson Quality control of markers in genome-wide association studies often includes testing for Hardy-Weinberg equilibrium (HWE). However, this is usually implemented in a homogeneous population without stratifying by sex. Previous work indicates sex-based selection at
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